The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2001
Filed:
Sep. 27, 1999
Applicant:
Inventors:
Wolfgang Pieken, Longmont, CO (US);
Diane Tasset, Boulder, CO (US);
Nebojsa Janjic, Lafayette, CO (US);
Larry Gold, Boulder, CO (US);
Gary P Kirschenheuter, Arvada, CO (US);
Assignee:
NeXstar Pharmaceuticals, Inc., Boulder, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07G 1/100 ; C07H 1/900 ; C07H 1/912 ; C07H 1/906 ; C07H 1/9048 ;
U.S. Cl.
CPC ...
C07G 1/100 ; C07H 1/900 ; C07H 1/912 ; C07H 1/906 ; C07H 1/9048 ;
Abstract
Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic acids containing nucleotides modified at the 2′- and 5-position. Specific 2-OH and 2′-NH,modified RNA ligands to thrombin are described.