Location History:
- St. Louis, MO (US) (2009 - 2014)
- Saint Louis, MO (US) (2011 - 2014)
Company Filing History:
5 out of 218 
2 out of 135 
1 out of 5 
Years Active: 2009-2014
Title: The Innovative Contributions of William S. Sly
Introduction
William S. Sly is a distinguished inventor based in St. Louis, Missouri, celebrated for his contributions to enzyme replacement therapies. With a remarkable portfolio of eight patents, Sly has made significant strides in the field of medical innovations, particularly concerning metabolic disorders in fetuses.
Latest Patents
Among his latest patents, Sly has developed groundbreaking methods for prenatal enzyme replacement therapy for hypophosphatasia (HPP). This innovative therapy involves administering a pharmaceutical composition containing a water-soluble tissue-nonspecific alkaline phosphatase (TNSALP) portion in combination with an IgG1 antibody Fc portion. This therapy can be delivered to a pregnant animal whose fetus or embryo requires treatment, allowing the protein to cross the placenta and restore normal metabolic activity in the fetal tissues.
Additionally, Sly's work encompasses compositions and methods for enzyme replacement therapy that utilize a soluble active form of the enzyme TNSALP by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. This approach is promising for treating hypophosphatasia and includes the development of oligo acid amino acid variants targeting bone tissue specifically.
Career Highlights
Sly's impressive career includes affiliations with prestigious institutions such as Saint Louis University and BioMarin Pharmaceutical Inc. His work has significantly advanced understandings of metabolic disorders, positioning him as a key figure in medical research and innovation.
Collaborations
Throughout his career, Sly has collaborated with notable individuals, including Jeffrey H. Grubb and Jonathan LeBowitz. These partnerships highlight the collaborative spirit within the scientific community, which is essential for advancing innovative solutions to complex medical challenges.
Conclusion
William S. Sly’s contributions to the field of enzyme replacement therapy demonstrate his commitment to advancing medical science and improving patient outcomes. His innovative patents reflect a deep understanding of biological processes and a dedication to addressing unmet medical needs, solidifying his legacy as a prominent inventor in the realm of medical innovations.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.