The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2014
Filed:
Jan. 17, 2011
William S. Sly, St. Louis, MO (US);
Jeffrey H. Grubb, Arnold, MO (US);
Shunjl Tomatsu, Clayton, MO (US);
Adriana Maria Monta{umlaut Over (N)}o Suarez, St. Louis, MO (US);
Hirotaka Oikawa, Singapore, SG;
William S. Sly, St. Louis, MO (US);
Jeffrey H. Grubb, Arnold, MO (US);
Shunjl Tomatsu, Clayton, MO (US);
Adriana Maria Monta{umlaut over (n)}o Suarez, St. Louis, MO (US);
Hirotaka Oikawa, Singapore, SG;
Saint Louis University, St. Louis, MO (US);
Abstract
Transplacental enzyme replacement therapy (ERT) is disclosed for deficiency of a polypeptide such as a tissue-nonspecific alkaline phosphatase (TNSALP) by administering a pharmaceutical composition that comprises a water-soluble TNSALP portion, e.g., C-terminus-truncated TNSALP peptide-bonded to an IgG1 antibody Fc portion, to a pregnant animal whose fetus or embryo is in need of such therapy. Also contemplated is a method for treating a metabolic disorder, such as HPP, in a fetus or embryo where a fusion protein that comprises a Fc fragment of an IgG1 antibody peptide-bonded to TNSALP is administered to a pregnant mother. The protein crosses the placenta of the mother and enters the fetal blood stream. The protein is taken up into fetal tissue such that the TNSALP restores normal metabolic activity in the fetus.