The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Mar. 24, 2011
Shunji Tomatsu, Saint Louis, MO (US);
William Sly, Saint Louis, MO (US);
Jeffrey Grubb, Saint Louis, MO (US);
Tatsuo Nishioka, Kanazawa, JP;
Ken-ichi Miyamoto, Kanazawa, JP;
Seiji Yamaguchi, Izumo, JP;
Shunji Tomatsu, Saint Louis, MO (US);
William Sly, Saint Louis, MO (US);
Jeffrey Grubb, Saint Louis, MO (US);
Tatsuo Nishioka, Kanazawa, JP;
Ken-ichi Miyamoto, Kanazawa, JP;
Seiji Yamaguchi, Izumo, JP;
Saint Louis University, St. Louis, MO (US);
Shimane University, Matsue, JP;
Kanazawa University, Kanazawa, JP;
Abstract
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue.