Tatsuo Nishioka

Title: Innovations by Tatsuo Nishioka

Introduction

Tatsuo Nishioka is a notable inventor based in Kanazawa, Japan. He has made significant contributions to the field of enzyme replacement therapy, with a focus on treating conditions such as hypophosphatasia and enhancing therapeutic effects on the central nervous system. Nishioka holds a total of 3 patents that reflect his innovative approaches in biotechnology.

Latest Patents

One of Nishioka's latest patents is titled "Compositions and methods for treating hypophosphatasia." This invention provides compositions and methods for use in enzyme replacement therapy. The patent discloses a method of producing membrane-bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. Specifically, the invention reveals a soluble active form of the membrane-bound enzyme TNSALP, produced by deleting the GPI anchor single peptide sequence. This composition is particularly useful for the treatment of hypophosphatasia.

Another significant patent is focused on "Enhancing the effect of therapeutic proteins on the central nervous system." This invention provides a polypeptide therapeutic agent that is useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The method involves enhancing the effect of a polypeptide or protein on the central nervous system by attaching a short acidic amino acid sequence. The patent specifically details the attachment of a 4-15 acidic amino acid sequence to human β-glucuronidase by constructing a fusion protein. This molecule is beneficial in treating type VII mucopolysaccharidosis when administered to patients.

Career Highlights

Throughout his career, Tatsuo Nishioka has worked with esteemed institutions such as Saint Louis University and Shimane University. His research has significantly advanced the understanding and treatment of various medical conditions through innovative enzyme therapies.

Collaborations

Nishioka has collaborated with notable individuals in his field, including Shunji Tomatsu and William S. Sly. These collaborations have contributed to the development of his groundbreaking patents and research.

Conclusion

Tatsuo Nishioka's contributions to enzyme replacement therapy and his innovative patents highlight his role as a significant inventor in the biotechnology field. His work continues to impact the treatment of serious medical conditions, showcasing the importance of innovation in healthcare.