The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Feb. 28, 2010
Shunji Tomatsu, Wilmington, DE (US);
Adriana Montano, St. Louis, MO (US);
Tatsuo Nishioka, Ishikawa, JP;
Jeffrey H. Grubb, St. Louis, MO (US);
William S. Sly, St. Louis, MO (US);
Monica A. Gutierrez, Cucuta Norte de Santander, CO;
Amelia Ortigoza Rodriguez, Legal Representative, Cucuta Norte de Santander, CO;
Shunji Tomatsu, Wilmington, DE (US);
Adriana Montano, St. Louis, MO (US);
Tatsuo Nishioka, Ishikawa, JP;
Jeffrey H. Grubb, St. Louis, MO (US);
William S. Sly, St. Louis, MO (US);
Monica A. Gutierrez, Cucuta Norte de Santander, CO;
Amelia Ortigoza Rodriguez, legal representative, Cucuta Norte de Santander, CO;
Saint Louis University, Saint Louis, MO (US);
Abstract
The present invention provides a polypeptide therapeutic agent, useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The invention provides a method of enhancing the effect of a polypeptide or protein on the central nervous system by the attachment of a short acidic amino acid sequence. Specifically the inventors disclose the attachment of a 4-15 acidic amino acid sequence to human β-glucuronidase by construction of a fusion protein. This molecule is useful in the treatment of type VII mucopolysaccharidosis when administered to a patient.