Location History:
- Saint Louis, MO (US) (2015 - 2018)
- St. Louis, MO (US) (2009 - 2022)
Company Filing History:
Years Active: 2009-2022
Title: Innovations and Contributions of Inventor Wenhua Chu
Introduction
Wenhua Chu is a prominent inventor based in St. Louis, MO (US), known for his significant contributions to the field of radiopharmaceuticals. With a total of seven patents to his name, he has made remarkable advancements in the synthesis of PET tracers, which are crucial for medical imaging.
Latest Patents
One of his latest patents involves synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride. This patent discloses methods for preparing reactive [F-18]fluoride in a form suitable for efficient radiolabeling without the need for an azeotropic evaporation step. The use of anion exchange resin and sulfonyl chloride enhances the manufacturing process of PET radiopharmaceuticals. Another notable patent focuses on radiolabeled tracers for poly (ADP-ribose) polymerase-1 (PARP-1). This patent reveals PARP-1 inhibitors that can be F-labeled for use as tracers in positron emission tomographic (PET) imaging. Among the synthesized compounds, 2-[p-(2-Fluoroethoxy)phenyl]-1.3.10-triazatricyclo[6.4.1.0]trideca-2,4(13),5,7-tetraen-9-one (12) exhibited the highest inhibition potency for PARP-1. The synthesis of [F]-12 is disclosed under conventional conditions, achieving high specific activity with a decay-corrected yield of 40-50%. MicroPET imaging using [F]-12 in MDA-MB-436 tumor-bearing mice demonstrated significant accumulation of [F]-12 in tumors, with binding that can be blocked by olaparib. These compounds have substantial utility for tumor imaging.
Career Highlights
Wenhua Chu is affiliated with Washington University, where he continues to contribute to research and innovation in the field of radiopharmaceuticals. His work has not only advanced scientific understanding but has also paved the way for improved diagnostic techniques in medicine.
Collaborations
He has collaborated with notable colleagues, including Robert H Mach and Dong Zhou, further enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Wenhua Chu's innovative work
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.