The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
Dec. 16, 2010
Applicants:
Robert H. Mach, Eureka, MO (US);
Mark Mintun, Villanova, PA (US);
Wenhua Chu, Saint Louis, MO (US);
Laura Dugan, San Diego, CA (US);
Inventors:
Robert H. Mach, Eureka, MO (US);
Mark Mintun, Villanova, PA (US);
Wenhua Chu, Saint Louis, MO (US);
Laura Dugan, San Diego, CA (US);
Assignee:
Washington University, Saint Louis, MO (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 221/12 (2006.01);
U.S. Cl.
CPC ...
C07D 221/12 (2013.01); C07D 401/12 (2013.01);
Abstract
Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed.