The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Aug. 29, 2007
Applicants:
Robert H. Mach, Eureka, MO (US);
Michael Welch, St. Louis, MO (US);
Wenhua Chu, St. Louis, MO (US);
Justin Rothfuss, St. Louis, MO (US);
Inventors:
Robert H. Mach, Eureka, MO (US);
Michael Welch, St. Louis, MO (US);
Wenhua Chu, St. Louis, MO (US);
Justin Rothfuss, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/404 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
Abstract
Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).