Location History:
- Creve Couer, MO (US) (2000)
- Clayton, MO (US) (2008 - 2013)
- St. Louis, MO (US) (1989 - 2015)
Company Filing History:
11 out of 1,579 
1 out of 45 Years Active: 1989-2015
Title: Innovations and Contributions of Michael John Welch
Introduction
Michael John Welch is a prominent inventor based in Clayton, MO (US), known for his significant contributions to the field of biomedical research. With a total of 11 patents to his name, Welch has made remarkable strides in developing innovative solutions for early diagnosis and therapy of cancer.
Latest Patents
Among his latest patents is the invention of cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) that target uniquely expressed or over-expressed mRNA sequences for cancer diagnosis and therapy. This functional biologically active particle conjugate is designed to diagnose and treat cancer effectively. It comprises a nanoscale particle associated with an intracellular targeting ligand, which includes a PNA or another nuclease-resistant oligonucleotide analog, such as MOE-mRNA or LNA. The sequence binds selectively to uniquely expressed or overexpressed mRNA specific to the cancer or disease state in living mammals. Notably, the unr mRNA can be targeted by the antisense sequence PNA50.
Another significant patent involves natriuretic peptide-mediated imaging of atherosclerotic plaque. This invention includes tracers comprising an oligopeptide fragment of a natriuretic peptide, specifically the sequence Arg-Ile-Asp-Arg-Ile, along with a signaling moiety. The methods disclosed allow for imaging atherosclerotic plaque using PET scanning or MRI with the developed tracer.
Career Highlights
Welch has had a distinguished career, working with reputable institutions such as Washington University and Science Research Laboratory, Inc. His work has focused on advancing medical technologies and improving diagnostic methods.
Collaborations
Throughout his career, Welch has collaborated with notable individuals, including Robert H Mach and Zhude Tu. These collaborations have contributed to the development of innovative solutions in the biomedical field.
Conclusion
Michael John Welch's contributions to the field of biomedical research through his patents and collaborations highlight his role as a leading inventor. His work continues to impact the diagnosis and treatment of critical health conditions, showcasing the importance of innovation in medicine.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.