The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Dec. 05, 2012
Washington University, St. Louis, MO (US);
Matthew L. Becker, St. Louis, MO (US);
Huafeng Fang, St. Louis, MO (US);
Xiaoxu Li, St. Louis, MO (US);
Dipanjan Pan, St. Louis, MO (US);
Raffaella Rossin, St. Louis, MO (US);
Xiankai Sun, St. Louis, MO (US);
John Stephen Taylor, St. Louis, MO (US);
Jeffrey L. Turner, St. Louis, MO (US);
Michael John Welch, St. Louis, MO (US);
Karen L. Wooley, St. Louis, MO (US);
WASHINGTON UNIVERSITY IN ST. LOUIS, St. Louis, MO (US);
Abstract
A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2'-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.