The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Aug. 28, 2009
Robert H. Mach, Eureka, MO (US);
Michael J. Welch, Clayton, MO (US);
Douglas J. Rowland, Davis, CA (US);
Zhude Tu, Eureka, MO (US);
Robert H. Mach, Eureka, MO (US);
Michael J. Welch, Clayton, MO (US);
Douglas J. Rowland, Davis, CA (US);
Zhude Tu, Eureka, MO (US);
Washington University, St. Louis, MO (US);
Abstract
Methods for detection of cancer cells and for determining the proliferative status of cells in a tissue sample in vitro are disclosed. These methods comprise contacting a tissue sample with a radiolabeled compound or salt thereof of Formula wherein at least one of X, Y, and Z comprises a radioisotope, n is an integer from 2 to about 10; and each of A and Ais a C-Calkoxyl, a C-Cfluoroalkyl or a C-Cfluoroalkoxyl. The methods further comprise detecting the distribution of the radioisotope in the tissue sample, whereby a cell having a high density of the radioisotope compared to quiescent cells is diagnostic for a cancer cell.