Location History:
- Richmond, CA (US) (2021 - 2024)
- Pinole, CA (US) (2024)
Company Filing History:
10 out of 11 
10 out of 11 
7 out of 57 
Years Active: 2021-2025
Title: Vita Golubovskaya: A Trailblazer in Biomedical Innovations
Introduction
Vita Golubovskaya, an innovative inventor based in Richmond, California, has made significant strides in the field of biomedical research. With a total of 16 patents to her name, Golubovskaya is recognized for her groundbreaking work in monoclonal antibodies and chimeric antigen receptor (CAR) technology. Her inventions are paving the way for advancements in targeted therapies and cancer treatment.
Latest Patents
Among her most notable patents are the Epcam antibody and Epcam-CAR-T cells. The Epcam antibody invention encompasses a humanized monoclonal anti-human EpCAM antibody, specifically a single-chain variable fragment (scFv), that includes the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. This invention also advances CAR-T cell therapy through a chimeric antigen receptor fusion protein composed of several parts: a scFv, a transmembrane domain, co-stimulatory domains, and an activating domain.
Another significant patent relates to CAR-T cells incorporating a humanized CD19 scFv that features a mutation in the CDR1 region. This innovation allows for enhanced specificity as the mutated CD19 scFv possesses the amino acid sequences of SEQ ID NO: 6 and SEQ ID NO: 5. The resulting humanized CD19-CAR-T cells exhibit specific killing activity alongside cytokine IFN-gamma secretion in both in vitro and in vivo settings.
Career Highlights
Golubovskaya's professional journey includes impactful roles at prominent companies such as Promab Biotechnologies, Inc. and Forevertek Biotechnology Co., Ltd. Her expertise has driven forward multiple research initiatives and innovations that address critical challenges in biomedical sciences.
Collaborations
Throughout her career, Vita has collaborated with esteemed peers, including Lijun Wu and Martyn Lewis. These partnerships have enabled her to leverage diverse expertise and insights, further enhancing the quality and applicability of her inventions.
Conclusion
Vita Golubovskaya stands as a remarkable figure in the world of biomedical innovation. With her impressive patent portfolio and collaborative spirit, she continues to contribute significantly to advancements in cancer therapies and related fields. Her journey serves as an inspiration to aspiring inventors and researchers striving to make impactful contributions to society through innovation.