The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
May. 31, 2023
Promab Biotechnologies, Inc., Richmond, CA (US);
Forevertek Biotechnology Co., Ltd, Changsha, CN;
Lijun Wu, Berkeley, CA (US);
Vita Golubovskaya, Pinole, CA (US);
ProMab Biotechnologies, Inc., Richmond, CA (US);
Forevertek Biotechnology Co., Ltd, Changsha, CN;
Abstract
The present invention is directed to a humanized BCMA antibody or an antigen-binding fragment thereof, comprising Vhaving the amino acid sequence of SEQ ID NO: 3 and Vhaving the amino acid sequence of SEQ ID NO: 5. The present invention is also directed to a BCMA chimeric antigen receptor fusion protein comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) of the present invention, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain. This humanized BCMA-CAR-T cells have specific killing activity against BCMA-positive tumor cells.