The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2022
Filed:
Feb. 22, 2019
Promab Biotechnologies, Inc., Richmond, CA (US);
Forevertek Biotechnology Co., Ltd, Hunan, CN;
The General Hospital Corporation, Boston, MA (US);
Lijun Wu, Albany, CA (US);
Marcela V. Maus, Lexington, MA (US);
Vita Golubovskaya, Richmond, CA (US);
ProMab Biotechnologies, Inc., Richmond, CA (US);
Forevertek Biotechnology Co., Ltd, Changsha, CN;
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention is directed to a chimeric antigen receptor (CAR) fusion protein comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) comprising Vand V, wherein scFv binds to a tumor antigen, (ii) a transmembrane domain, (iii) a co-stimulatory domain of GITR intracellular domain, and (iv) an activating domain. In one embodiment, the tumor antigen is human epidermal growth factor receptor (EGFR), human mesothelin, or human CD19. CARs having GITR intracellular domain as a co-stimulatory domain have certain advantages over other traditional CAR co-stimulatory domains.