The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 21, 2025

Filed:

Feb. 23, 2022
Applicants:

Promab Biotechnologies, Inc., Richmond, CA (US);

Forevertek Biotechnology Co., Ltd, Changsha, CN;

Inventors:

Lijun Wu, Albany, CA (US);

Vita Golubovskaya, Richmond, CA (US);

Assignees:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4202 (2025.01); C07K 14/7051 (2013.01); C07K 14/70596 (2013.01); A61K 2239/28 (2023.05); A61K 2239/31 (2023.05); A61K 2239/46 (2023.05); A61P 35/00 (2018.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C12N 15/63 (2013.01);
Abstract

The present invention is directed to a monoclonal anti-human CS1 antibody or a single-chain variable fragment (scFv), comprising VH having the amino acid of SEQ ID NO: 3 and VL having the amino acid of SEQ ID NO: 7. The present invention is also directed to a chimeric antigen receptor fusion protein comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) of the present invention, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain.


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