Victor Matvienko

Title: Victor Matvienko: Innovator in Anticancer Drug Synthesis

Introduction

Victor Matvienko is a prominent inventor based in Kharkiv, Ukraine. He has made significant contributions to the field of medicinal chemistry, particularly in the synthesis of anticancer drugs. With a total of 8 patents to his name, Matvienko's work has the potential to impact cancer treatment significantly.

Latest Patents

Among his latest patents is a method for the synthesis of clofarabine. This invention relates to a high-yield production process for the anticancer nucleoside clofarabine. The method involves the preparation of 2-chloroadenosine through enzymatic transglycosylation between 2-chloroadenine and nucleosides, followed by benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection. Another notable patent is a method for preparing 4-demethyldaunorubicin. This method utilizes daunorubicin as a starting material and involves reacting it with soft Lewis acids for the demethylation of the 4-methoxy group. The resulting reaction mass is treated with an aqueous solution of a strong organic acid or a mineral acid, leading to the extraction of carminomycin as a base.

Career Highlights

Victor Matvienko has worked with several companies throughout his career, including Solux Corporation and Synbias Pharma AG. His experience in these organizations has allowed him to refine his skills in drug synthesis and development.

Collaborations

Matvienko has collaborated with notable colleagues such as Alexander F. Zabudkin and Aleksandr M. Itkin. These partnerships have contributed to his innovative approaches in the field of medicinal chemistry.

Conclusion

Victor Matvienko's contributions to the synthesis of anticancer drugs highlight his role as a key innovator in the pharmaceutical industry. His patents and collaborations reflect a commitment to advancing cancer treatment through innovative methodologies.