The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2013
Filed:
May. 23, 2008
Alexander F. Zabudkin, Donetsk, UA;
Victor Matvienko, Donetsk, UA;
Alexey Matveev, Donetsk, UA;
Aleksandr M. Itkin, San Diego, CA (US);
Alexander F. Zabudkin, Donetsk, UA;
Victor Matvienko, Donetsk, UA;
Alexey Matveev, Donetsk, UA;
Aleksandr M. Itkin, San Diego, CA (US);
Solux Corporation, San Diego, CA (US);
Abstract
A method for the aralkylation of anthracyclins by utilizing an aralkylating agent R—CHX (for example, BnBr) in accordance with the reaction pathway describe by the scheme shown in FIG.. The present invention recognizes that 4-R, 3'-N-Daunomycines are suitable substrates for selective 4′-O-benzylation, yielding 4-R, 3′-N-4′-O-Aralkyl-Daunorubicines (in particular, 4′-O-Bn-Daunomycines). Thus, the present invention provides a pathway for a simple production of 4′-O-aralkylated derivatives of anthracyclines which can be effectively used to produce anthracyclines.