The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2014
Filed:
Apr. 29, 2011
Applicants:
Alexander Zabudkin, Donetsk, UA;
Victor Matvienko, Donetsk, UA;
Alexey Matvyeyev, Donetsk, UA;
Inventors:
Assignee:
Synbias Pharma AG, , CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 15/252 (2006.01);
U.S. Cl.
CPC ...
C07H 15/252 (2013.01);
Abstract
The present invention relates to a method for the synthesis of 4-demethoxydaunorubicin (idarubicin) having the chemical structure of formula (I), which involves the demethylation of 3'-Prot-daunorubicin in the presence of a soft Lewis acid. The method of the present invention does not comprise cleavage of the glycosidic linkage at carbon C7, thus resulting in a faster synthesis cycle and an improved yield of the final product.