Location History:
- Chagrin Falls, OH (US) (1978)
- Morganville, NJ (US) (1991)
- Saratoga, CA (US) (2014 - 2017)
- San Jose, CA (US) (2013 - 2022)
- Cupertino, CA (US) (2019 - 2024)
- South San Francisco, CA (US) (2024)
Company Filing History:
11 out of 71 
2 out of 2 
1 out of 1 
Years Active: 1978-2025
Title: Thomas Brennan: Innovator in Cancer Treatment
Introduction
Thomas Brennan is a prominent inventor based in San Jose, CA, known for his significant contributions to the field of cancer treatment. With a total of 17 patents to his name, he has made remarkable advancements in medical technology and therapeutic methods.
Latest Patents
Brennan's latest patents include groundbreaking work on CD80 extracellular domain polypeptides and their use in cancer treatment. This patent provides antibodies and antigen-binding fragments that specifically bind to human B7-H4, which can enhance T cell proliferation and increase interferon-gamma production. Additionally, these antibodies can deplete B7-H4 expressing cells through ADCC activity. Another notable patent involves genetically modified B cells, which are designed for the treatment of various diseases, including cancer and heart disease. These modified B cells, known as CAR-B cells, are capable of expressing a chimeric receptor that can deliver therapeutic payloads.
Career Highlights
Throughout his career, Thomas Brennan has worked with several notable companies, including Five Prime Therapeutics, Inc. His work has focused on innovative solutions that address critical health challenges, particularly in oncology.
Collaborations
Brennan has collaborated with esteemed colleagues such as David Bellovin and Barbara Sennino, contributing to the advancement of research and development in his field.
Conclusion
Thomas Brennan's innovative work in cancer treatment exemplifies the impact of dedicated inventors in the medical field. His patents and collaborations continue to pave the way for new therapeutic approaches that can significantly improve patient outcomes.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.