The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2024
Filed:
Sep. 02, 2021
Walking Fish Therapeutics, South San Francisco, CA (US);
Kathleen Boyle, Alameda, CA (US);
Hangil Park, San Francisco, CA (US);
Srinivas Kothakota, Pacifica, CA (US);
Mark Selby, San Francisco, CA (US);
Thomas Brennan, Cupertino, CA (US);
Lewis T. Williams, Mill Valley, CA (US);
Walking Fish Therapeutics, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to genetically modified B cells and their uses thereof, for example, for the treatment of a variety of diseases and disorders, including cancer, heart disease, inflammatory disease, muscle wasting disease, neurological disease, and the like. In certain embodiments, the invention relates to an isolated modified B cell ('CAR-B cell), capable of expressing a chimeric receptor (“CAR-B receptor'), wherein said chimeric receptor comprises (a) an extracellular domain; (b) a transmembrane domain; and (c) a cytoplasmic domain that comprises at least one signaling domain. In various embodiments, the invention comprises an isolated modified B cell, wherein said B cell is capable of expressing and secreting a payload, wherein the payload is not naturally expressed in a B cell or is expressed at higher levels than is naturally expressed in a B cell. In various embodiments, the payload is an antibody or fragment thereof.