Srinivas Kothakota

Title: Innovations of Srinivas Kothakota

Introduction

Srinivas Kothakota is a notable inventor based in Pacifica, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of genetically modified B cells. With a total of 3 patents to his name, Kothakota's work has the potential to impact various medical treatments.

Latest Patents

One of Kothakota's latest patents is titled "Modified B cells and methods of use thereof." This invention relates to genetically modified B cells and their applications in treating a variety of diseases and disorders, including cancer, heart disease, inflammatory diseases, muscle wasting diseases, and neurological disorders. The invention features an isolated modified B cell, referred to as a 'CAR-B cell,' which is capable of expressing a chimeric receptor known as the “CAR-B receptor.” This chimeric receptor comprises an extracellular domain, a transmembrane domain, and a cytoplasmic domain that includes at least one signaling domain. Additionally, the invention encompasses a modified B cell that can express and secrete a payload, which may be an antibody or a fragment thereof, that is not naturally expressed in a B cell or is expressed at higher levels than normally found.

Career Highlights

Throughout his career, Kothakota has worked with several prominent companies in the biotechnology sector. Notable among these are Walking Fish Therapeutics and Five Prime Therapeutics, Inc. His experience in these organizations has contributed to his expertise in the field and has facilitated his innovative work.

Collaborations

Kothakota has collaborated with several professionals in his field, including Lewis T. Williams and Hangil Park. These collaborations have likely enriched his research and development efforts.

Conclusion

Srinivas Kothakota's contributions to biotechnology, particularly through his patented innovations in modified B cells, showcase his commitment to advancing medical science. His work holds promise for the treatment of various diseases, highlighting the importance of innovation in healthcare.