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For the Inventor, By the Inventor

Ann Arbor, MI, United States of America

Sylvester R Klutchko

USPTO Granted Patents = 30

Average Co-Inventor Count = 2.6

ph-index = 9

Forward Citations = 474(Granted Patents)


Location History:

  • Hackettstown, NJ (US) (1976 - 1978)
  • Ann Arbor, MI (US) (1978 - 2006)

Company Filing History:

goldMedal30 out of 2,538 
 
Warner-Lambert Company
 patents

Years Active: 1976-2006

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30 patents (USPTO):Explore Patents
1. 7022711 - 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7-ones (2006-04-04),
2. 5733914 - Pyrido�2, 3-d!pyrimidines for inhibiting protein tyrosine kinase (1998-03-31),
3. 5658943 - Phenylalanine derivatives as endothelin antagonists (1997-08-19),
4. 5620981 - Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase (1997-04-15),
5. 5525614 - Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor (1996-06-11),
6. 5489686 - Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor (1996-02-06),
7. 5436260 - Angiotensin II receptor antagonists (1995-07-25),
8. 5350757 - Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor (1994-09-27),
9. 5308853 - Substituted-5-methylidene hydantoins with AT.sub.1 receptor antagonist (1994-05-03),
10. 5246943 - Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor (1993-09-21),
11. 5198426 - Renin inhibitors containing C-terminal dihydroxy amides (1993-03-30),
12. 5061808 - 2-oxo-1-pyrrolidine carboxylic acid esters (1991-10-29),
13. 4876343 - Process for statine and statine analogs (1989-10-24),
14. 4816463 - Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive (1989-03-28),
15. 4812462 - 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs (1989-03-14),

Title: Sylvester R. Klutchko: A Pioneer in Medicinal Chemistry

Introduction: Sylvester R. Klutchko is a distinguished inventor based in Ann Arbor, MI, with an impressive portfolio comprising 30 patents. His contributions to the field of medicinal chemistry have played a significant role in the development of innovative therapeutic compounds to address various diseases, including cancer.

Latest Patents: Among his latest patents, Klutchko has developed two notable inventions. The first patent, titled "2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7-ones," presents antiangiogenic compounds that have the potential to treat diseases resulting from uncontrolled cellular proliferation, such as cancer, atherosclerosis, rheumatoid arthritis, and psoriasis. The second patent involves "Pyrido[2,3-d]pyrimidines for inhibiting protein tyrosine kinase." This invention features 6-Aryl pyrido[2,3-d]pyrimidine 7-imines, 7-ones, and 7-thiones, which serve as inhibitors of protein tyrosine kinases, offering therapeutic benefits in treating cancer, atherosclerosis, restenosis, and psoriasis.

Career Highlights: Sylvester R. Klutchko has made a mark in the pharmaceutical industry through his work with Warner-Lambert Company. His deep understanding of chemical compounds and their biological implications has led to groundbreaking advancements in drug development.

Collaborations: Throughout his career, Klutchko has collaborated with esteemed colleagues, including John C. Hodges and Clifton J. Blankley. Their combined expertise has contributed to the successful innovation of multiple therapeutic compounds.

Conclusion: Sylvester R. Klutchko's contributions to the field of medicinal chemistry demonstrate the impact that dedicated inventors have on addressing critical health challenges. His innovative patents and collaborations continue to pave the way for new treatments, underscoring the importance of research and development in pharmaceuticals.

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