Location History:
- Del Mar, CA (US) (2007 - 2008)
- San Diego, CA (US) (2014 - 2024)
Company Filing History:
Years Active: 2007-2024
Title: Innovations of Stephen A. Chappell
Introduction
Stephen A. Chappell is a notable inventor based in Del Mar, California. He has made significant contributions to the field of biotechnology, particularly in the areas of DNA assembly and immunotherapy. With a total of six patents to his name, Chappell's work is at the forefront of innovative solutions for data storage and vaccine development.
Latest Patents
One of Chappell's latest patents is titled "Optical methods and systems for DNA assembly for computer data storage." This invention describes an array-based system that utilizes assembled DNA for storing computer data. The system features an array surface with immobilized seed DNA that has blunt ends, which are connected to a photocleavable optical linker. When a light source is applied, the linker is broken, creating a sticky end that facilitates hybridization. Data-bearing DNA cassettes can then attach to the array via these sticky ends, with the attachment being made permanent through the use of ligase.
Another significant patent is focused on "Materials and methods for cell-free expression of vaccine epitope concatemers." This disclosure provides innovative materials and methods for expressing concatenated epitopes, which are crucial for immunotherapy applications. The approach utilizes a cell-free protein synthesis platform, enabling high throughput and large-scale epitope screening, as well as the generation of multi-epitope vaccines.
Career Highlights
Chappell has had a distinguished career, working with prominent organizations such as The Scripps Research Institute and Leidos, Inc. His experience in these institutions has allowed him to collaborate on groundbreaking research and development projects.
Collaborations
Throughout his career, Chappell has worked alongside esteemed colleagues, including Vincent P. Mauro and Gerald M. Edelman. These collaborations have further enriched his contributions to the field of biotechnology.
Conclusion
Stephen A. Chappell's innovative work in DNA assembly and immunotherapy exemplifies the impact of his inventions on modern science. His patents reflect a commitment to advancing technology for practical applications in data storage and healthcare.