The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Feb. 24, 2010
Vincent P. Mauro, San Diego, CA (US);
Stephen A. Chappell, San Diego, CA (US);
Wei Zhou, San Diego, CA (US);
Gerald M. Edelman, San Diego, CA (US);
Vincent P. Mauro, San Diego, CA (US);
Stephen A. Chappell, San Diego, CA (US);
Wei Zhou, San Diego, CA (US);
Gerald M. Edelman, San Diego, CA (US);
The Scripps Research Institute, LaJolla, CA (US);
Abstract
Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3' UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA-mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences.