Shannon Tessier

Title: Innovations in Cryopreservation by Shannon Tessier

Introduction

Shannon Tessier is a prominent inventor based in Cambridge, MA, known for her significant contributions to the field of cryopreservation. With a total of five patents to her name, Tessier has made remarkable advancements in the preservation of biological samples, particularly organs and tissues.

Latest Patents

One of her latest patents focuses on the cryopreservation of tissues and organs. This disclosure outlines methods for preserving biological samples, such as entire organs from mammals, including humans. The innovation is based on the discovery that biological tissue samples can be supercooled while minimizing ice crystal formation. This is achieved by reducing liquid-air interfaces and lowering the melting point of the tissue samples through the use of cryoprotective agents. The methods ensure uniform distribution of these agents throughout the biological sample by employing improved perfusion techniques.

Another notable patent by Tessier is related to high subzero cryopreservation. This disclosure presents methods for preserving biological samples, organs, and organisms. It highlights the discovery that endothelial cells exhibit improved attachment and viability after preservation in the presence of heterogeneous extracellular ice. By uniformly nucleating ice across the microvasculature using ice nucleating agents, the risk of intracellular ice formation can be significantly reduced.

Career Highlights

Shannon Tessier works at The General Hospital Corporation, where she continues to innovate in the field of cryopreservation. Her work has the potential to revolutionize how biological samples are preserved, which is crucial for medical applications and research.

Collaborations

Tessier collaborates with esteemed colleagues, including Mehmet Toner and Shannon Stott, who contribute to her research efforts and advancements in cryopreservation techniques.

Conclusion

Shannon Tessier's innovative work in cryopreservation is paving the way for new methods of preserving biological samples, which could have significant implications for medical science. Her contributions are vital in enhancing the viability of preserved tissues and organs, ultimately benefiting the field of medicine.