The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Jun. 14, 2018
The General Hospital Corporation, Boston, MA (US);
Mehmet Toner, Charlestown, MA (US);
Mustafa Korkut Uygun, Newton, MA (US);
Shannon N. Tessier, Framingham, MA (US);
Shannon L. Stott, Stoneham, MA (US);
Lindong Weng, Arlington, MA (US);
Reinier Johan De Vries, Boston, MA (US);
Casie A. Pendexter, Rockland, MA (US);
Stephanie E J Cronin, Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
This disclosure is related to methods of preserving biological samples, organs, and organisms. This disclosure is based, at least in part, on the discovery that in the presence of heterogenous extracellular ice, endothelial cells have improved attachment and viability after preservation, and particularly by uniformly nucleating ice across the microvasculature using ice nucleating agents, the chance of intracelluar ice formation can be significantly reduced.