This inventor holds 7 USPTO granted patents. Top assignees: Health Research, Inc., Government of the USA, Nat'l Institute of Standards. Active years: 1997-2006.
Company Filing History:
7 out of 313 
1 out of 1 Years Active: 1997-2006
Title: Innovations of Sek Wen Hui in Liposomal Drug Delivery
Introduction
Sek Wen Hui is an accomplished inventor based in Williamsville, NY (US), known for his significant contributions to the field of drug delivery systems. With a total of seven patents to his name, he has focused on developing innovative liposomal compositions that enhance the targeted delivery of therapeutic agents.
Latest Patents
One of his latest patents is titled "Temperature Sensitive Control of Liposome-Cell Adhesion." This invention provides a liposomal composition designed for the targeted delivery of drugs. The composition includes poloxamer molecules and liposomes that encapsulate one or more delivery agents. At temperatures above the critical micellar temperature of the poloxamer, some poloxamer molecules form micelles while others integrate into the liposome surface, preventing adhesion to cells. Conversely, when the temperature drops below this critical point, the poloxamer molecules dissociate, allowing liposomes to adhere to adjacent cells and retain in surrounding tissue. The method involves administering the composition to an individual and cooling the target site to enhance liposome retention.
Another notable patent is "Temperature Controlled Content Release from Liposomes." This invention also focuses on a liposomal composition for drug delivery, comprising large unilamellar vesicles (LUV) that encapsulate poloxamers and delivery agents. The concentration of poloxamer within the LUVs is such that heating above the critical micellar temperature causes the LUVs to become leaky, resulting in the release of the encapsulated drug. This patent also outlines methods for delivering agents to targeted sites and preparing suitable LUVs.
Career Highlights
Throughout his career, Sek Wen Hui has worked with reputable organizations, including Health Research, Inc. and the National Institute of Standards and Technology (NIST) under the Government of the USA. His work has significantly advanced the understanding and application of liposomal drug delivery systems.
Collaborations
Sek has collaborated with notable colleagues such as Arindam Sen and Ya Li Zhao, contributing to the development of innovative solutions in drug delivery.
Conclusion
Sek Wen Hui's innovative work in liposomal drug delivery systems has the potential to revolutionize targeted therapies. His patents reflect a deep understanding of the mechanisms involved in drug delivery, paving the way for more effective treatments.