Location History:
- Baltimore, MD (US) (1999 - 2003)
- Chicago, IL (US) (2002 - 2005)
Company Filing History:
1 out of 3,688 
1 out of 2,313 
1 out of 194 
Years Active: 1999-2005
Title: **Sangram S Sisodia: A Pioneer in Alzheimer's Research**
Introduction
Sangram S Sisodia is an impactful inventor based in Chicago, IL, recognized for his significant contributions to the field of Alzheimer's disease research. With a portfolio that includes five patents, his work has focused on innovative diagnostic methods and transgenic animal models that pave the way for better drug screening and understanding of Alzheimer's disease pathology.
Latest Patents
One of Sangram S Sisodia's latest patents involves diagnostic methods for drug screening specifically tailored for Alzheimer's disease. This invention describes methods of screening candidate drugs by utilizing tissue slices from mutant mouse hippocampal cells. These cells, which possess an extra copy of a mutant form of the presenilin-1 gene, demonstrate enhanced potentiation in response to tetanic stimuli. The screening process compares the effects of candidate drugs on both wild-type and mutant cells, aiming to reduce enhanced potentiation in mutants without affecting wild-type cells.
Another notable patent he holds pertains to the development of transgenic mice expressing mutant human amyloid precursor protein (APP). This transgenic model is significant for studying age-related central nervous system disorders, which manifest as agitation, seizures, and diminished cerebral glucose utilization. The disorder's progression in these mice is directly correlated with brain levels of transgenic APP, indicating critical insights into the pathogenic activities of APP separate from amyloid formation.
Career Highlights
Sangram S Sisodia has made substantial contributions during his career, particularly through his association with institutions like The Johns Hopkins University. His work in the field of neuroscience and his innovative approaches to Alzheimer's research have placed him at the forefront of efforts aimed at understanding and treating this complex disease.
Collaborations
Throughout his career, Sangram has collaborated with esteemed colleagues in the field, including David R Borchelt and Karen Hsiao. These partnerships have fostered a collaborative environment that promotes the exchange of ideas and advancements in Alzheimer’s research and therapeutic strategies.
Conclusion
Sangram S Sisodia's innovative patents and collaborative efforts have made a lasting impact on Alzheimer's disease research. Through his dedication and pioneering work, he continues to shape the future of diagnostic methods and therapeutic approaches for this challenging condition, providing hope for effective treatments.