The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2005
Filed:
Jul. 14, 1999
Roberto Malinow, Cold Sprg Hrb, NY (US);
Shahid Zaman, Cold Spring Harbor, NY (US);
Sangram S. Sisodia, Chicago, IL (US);
David R. Borchelt, Baltimore, MD (US);
Michael K. Lee, Baltimore, MD (US);
Roberto Malinow, Cold Sprg Hrb, NY (US);
Shahid Zaman, Cold Spring Harbor, NY (US);
Sangram S. Sisodia, Chicago, IL (US);
David R. Borchelt, Baltimore, MD (US);
Michael K. Lee, Baltimore, MD (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Abstract
Methods of screening candidate drugs for the treatment of Alzheimer's disease are provided. Employing tissue slices of mutant mouse hippocampal cells having an extra copy of a mutant form of the presenilin-1 gene, it is found that these cells have enhanced potentiation to tetanic stimuli. By subjecting both wild-type and mutant hippocampal cells to tetanic stimuli in the presence of a candidate drug, reduction of the enhanced potentiation of the mutant cells without significant change in the potentiation of the wild-type cells indicates a successful candidate.