Company Filing History:
9 out of 932 
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1 out of 1 Years Active: 2010-2020
Title: **Robert A. Holt: Innovator in T-Cell Epitope Identification and Gene Expression**
Introduction
Robert A. Holt is a notable inventor based in North Vancouver, Canada, recognized for his impactful contributions in the field of immunology and gene expression. With a portfolio of 13 patents, Holt's innovations have advanced our understanding of T-cell epitope recognition and gene regulatory mechanisms.
Latest Patents
Among his latest patents, Holt has developed a method for T-cell epitope identification. This innovative method enables the determination of epitopes recognized by T-cells, enhancing the ability to analyze immune responses. The process involves expressing a library of candidate epitope sequences in recipient reporter cells. These cells provide detectable signals in response to cytotoxic attacks from cognate T-cells. The method further includes isolating reporter cells that have experienced a T-cell attack and analyzing them through next-generation sequencing to identify specific epitope sequences.
Another of his recent patents involves the discovery of isolated polynucleotides comprising TNNT1 mini-promoters. These mini-promoters can be operably linked to expressible sequences, aiding in the expression of genes of interest. This technology has applications in cell monitoring, gene therapy, and labeling, which are pivotal in both research and clinical settings.
Career Highlights
Holt has made significant contributions during his tenure at the University of British Columbia and the British Columbia Cancer Agency Branch. His research has led to advancements in cancer research and therapeutics, ultimately seeking to improve patient outcomes and therapeutic strategies.
Collaborations
Throughout his career, Holt has collaborated with esteemed professionals, including Steven J. Jones and Elizabeth M. Simpson. These collaborations have fostered innovative research and helped push the boundaries of scientific discovery in immunology and molecular biology.
Conclusion
Robert A. Holt continues to be a leading figure in the field of T-cell research and gene regulation, driving notable advancements through his inventive work. With a foundation built on empirical research and collaboration, his contributions are expected to leave a lasting impact on medical science and innovation.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.