Inventors with similar research interests:
Location History:
- Warsaw, Pasteura 1, PL (1991)
- Pasteura, PL (1995)
- Madison, WI (US) (1985 - 2010)
- Warsaw, PL (1988 - 2017)
Company Filing History:
100 out of 4,119 
1 out of 832,680 Years Active: 1985-2017
Title: Rafal R Sicinski: Pioneering Innovations in Vitamin D Analogues
Introduction:
Rafal R Sicinski is a renowned inventor based in Warsaw, Poland, known for his exceptional work in the field of pharmaceuticals. With an impressive portfolio of 99 patents, Sicinski has demonstrated expertise in synthesizing and exploring the biological activities of vitamin D analogues. His inventions have significant implications for the treatment and prevention of bone diseases, as well as anti-cancer applications.
Latest Patents:
Sicinski's recent patents focus on the synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds. These compounds, including 1α-hydroxy-2-methylene-vitamin D, (20S)-1α-hydroxy-2-methylene-vitamin D, and (5E)-1α,25-dihydroxy-2-methylene-vitamin D, have been found to possess various pharmaceutical uses, particularly in the treatment and prevention of bone diseases and disorders.
Another notable patent by Sicinski encompasses 3-desoxy-2-methylene-19-nor-vitamin D analogs, such as (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D and (20R)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D. These compounds exhibit significant binding activity and demonstrate potential as anti-cancer agents, specifically for osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer, and prostate cancer. Additionally, they show remarkable calcemic activity, making them useful in the treatment of bone diseases.
Work Experience:
Rafal R Sicinski has collaborated with esteemed organizations during his career. One of his notable affiliations includes the Wisconsin Alumni Research Foundation (WARF). WARF is an independent, nonprofit organization associated with the University of Wisconsin-Madison, focused on patenting and licensing inventions arising from university research. Sicinski's work with WARF further emphasizes the significance of his contributions in pharmaceutical research.
Co-workers and Collaborators:
Throughout his professional journey, Sicinski has had the privilege of collaborating with notable individuals, including Hector Floyd Deluca. Deluca, a distinguished scientist, is widely recognized for his groundbreaking contributions to the field of biochemistry and his extensive research on vitamin D. His partnership with Sicinski likely brought substantial expertise and knowledge to their collective projects.
Conclusion:
Rafal R Sicinski's innovative efforts in synthesizing vitamin D analogues have paved the way for advancements in pharmacology, specifically in the treatment and prevention of bone diseases. His latest patents highlight the potential of 2-methylene analogs and 3-desoxy-2-methylene-19-nor-vitamin D analogs as useful compounds in various pharmaceutical applications. Sicinski's collaboration with esteemed organizations and renowned co-workers demonstrates the significance of his contributions to the scientific community.
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