The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2013
Filed:
Oct. 21, 2011
Hector F. Deluca, Deerfield, WI (US);
Izabela Sibliska, Warsaw, PL;
Lori A. Plum, Arena, WI (US);
Margaret Clagett-dame, Deerfield, WI (US);
Rafal R. Sicinski, Warsaw, PL;
Katarzyna M. Barycka, Madison, WI (US);
Katarzyna Plonska-ocypa, Warsaw, PL;
Rafal Barycki, Warsaw, PL;
Hector F. DeLuca, Deerfield, WI (US);
Izabela Sibliska, Warsaw, PL;
Lori A. Plum, Arena, WI (US);
Margaret Clagett-Dame, Deerfield, WI (US);
Rafal R. Sicinski, Warsaw, PL;
Katarzyna M. Barycka, Madison, WI (US);
Katarzyna Plonska-Ocypa, Warsaw, PL;
Rafal Barycki, Warsaw, PL;
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
This invention discloses 2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-19-nor-vitamin Dand (20R)-25-hydroxy-2-methylene-19-nor-vitamin D, as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. Although these compounds have relatively low calcemic activities they may also be useful in the treatment of bone diseases due to their ability to act as prodrugs in vivo.