The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2012
Filed:
Sep. 30, 2010
Hector F. Deluca, Deerfield, WI (US);
Katarzyna Sokolowska, Lomza, PL;
Lori A. Plum, Arena, WI (US);
Margaret Clagett-dame, Deerfield, WI (US);
Rafal R. Sicinski, Warsaw, PL;
Antonio Mouriño, Ames, ES;
Hector F. DeLuca, Deerfield, WI (US);
Katarzyna Sokolowska, Lomza, PL;
Lori A. Plum, Arena, WI (US);
Margaret Clagett-Dame, Deerfield, WI (US);
Rafal R. Sicinski, Warsaw, PL;
Antonio Mouriño, Ames, ES;
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
This invention discloses 6-methylvitamin Danalogs, and specifically 1α,25-dihydroxy-6-methylvitamin D, and pharmaceutical uses therefor. This compound exhibits vitamin D receptor binding activity and transcription activity as well as activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent, especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. This compound also exhibits low in vivo calcemic activity, but because it binds the receptor with the same affinity as the native hormone calcitriol, it may act as an antagonist to inhibit development of hypercalcemia.