Paul Warren Tillberg

Title: Paul Warren Tillberg: Innovator in Microscopy and Nanofabrication

Introduction

Paul Warren Tillberg is a prominent inventor based in Cambridge, MA (US), known for his significant contributions to the fields of microscopy and nanofabrication. With a total of six patents to his name, Tillberg has developed innovative methodologies that enhance imaging techniques and material fabrication.

Latest Patents

One of his latest patents is titled "Iterative Expansion Microscopy." This invention leverages techniques for expansion microscopy (ExM) to provide an improved high-throughput super-resolution whole-organ imaging methodology. It allows for the imaging of protein architectures over whole organs with nanoscale resolution by using high-throughput microscopes in combination with samples that have been iteratively expanded multiple times. The method, referred to as 'iterative expansion microscopy' (iExM), enables biological samples to be permeated with a swellable material, resulting in isotropic expansion in three dimensions. This process can be applied to samples that have already undergone expansion using ExM techniques, allowing for significant linear expansion.

Another notable patent is "Three-Dimensional Nanofabrication by Patterning of Hydrogels." This invention enables three-dimensional nanofabrication through isotropic shrinking of patterned hydrogels. The process begins with an expanded hydrogel, where the rate of expansion is controlled by the concentration of the crosslinker. The hydrogel is infused with a reactive group and patterned in three dimensions using a photon beam through a limited-diffraction microscope. After functional particles or materials are deposited on the pattern, the hydrogel is shrunk and cleaved from the pattern.

Career Highlights

Throughout his career, Paul Warren Tillberg has worked with prestigious institutions such as the Massachusetts Institute of Technology and Harvard College. His work has significantly advanced the understanding and application of microscopy and nanofabrication techniques.

Collaborations

Tillberg has collaborated with notable individuals in his field, including Edward Stuart Boyden and Fei Chen. Their joint efforts have contributed to the development of innovative technologies that push the boundaries of scientific research.

Conclusion

Paul Warren Tillberg's contributions to microscopy and nanofabrication exemplify the spirit of innovation in scientific research. His patents reflect a commitment to advancing technology and enhancing our understanding of complex biological systems.