Location History:
- Somerville, MA (US) (2009)
- Boston, MA (US) (2013)
- Brookline, MA (US) (2009 - 2014)
Company Filing History:
8 out of 2,405 
5 out of 1,970 
2 out of 4,770 
Years Active: 2009-2014
Title: The Innovative Contributions of Paul A. Tempest
Introduction
Paul A. Tempest is a notable inventor based in Brookline, MA, who has made significant contributions to the field of pharmaceuticals. With a total of 14 patents to his name, Tempest has focused on developing compounds that address critical health issues, particularly in the areas of cancer and neurodegenerative diseases.
Latest Patents
Among his latest patents, Tempest has developed multi-cyclic compounds and methods of use. This invention relates to compounds capable of modulating various protein kinase receptors, such as Tie-2 and Aurora. These compounds are designed to treat cancer caused by unregulated angiogenesis and inflammation, as well as other proliferative disorders. Another significant patent involves cyclobutyl sulfones as notch-sparing gamma secretase inhibitors. This novel class of cyclobutyl sulfone derivatives inhibits the processing of APP by the putative gamma-secretase while sparing the Notch signaling pathway. This innovation is particularly useful in the treatment or prevention of Alzheimer's disease without causing gastrointestinal issues related to Notch inhibition.
Career Highlights
Throughout his career, Tempest has worked with prominent companies in the pharmaceutical industry, including Merck Sharp & Dohme Corporation and Amgen Inc. His work has been instrumental in advancing the understanding and treatment of various diseases through innovative pharmaceutical compositions.
Collaborations
Tempest has collaborated with notable professionals in his field, including Thomas Allen Miller and Solomon D. Kattar. These collaborations have further enriched his research and development efforts, leading to impactful innovations.
Conclusion
Paul A. Tempest's contributions to the field of pharmaceuticals through his patents and collaborations highlight his commitment to addressing significant health challenges. His innovative work continues to influence the development of treatments for critical diseases.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.