The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2013
Filed:
Nov. 22, 2010
Stephanie D. Geuns-meyer, Medford, MA (US);
Brian L. Hodous, Cambridge, MA (US);
Stuart C. Chaffee, Boston, MA (US);
Paul Tempest, Boston, MA (US);
Ning Xi, Thousand Oaks, CA (US);
Phillip R. Olivieri, Charlestown, MA (US);
Joseph L. Kim, Wayland, MA (US);
Steven Bellon, Wellesley, MA (US);
Xiaotian Zhu, Newton, MA (US);
Yuan Cheng, Newbury Park, CA (US);
Brian K. Albrecht, Cambridge, MA (US);
Vinod F. Patel, Acton, MA (US);
Victor J. Cee, Thousand Oaks, CA (US);
Karina Romero, Cambridge, MA (US);
Hanh Nho Nguyen, Arlington, MA (US);
Holly L. Deak, Brookline, MA (US);
Rebecca E. Johnson, Arlington, VA (US);
Stephanie D. Geuns-Meyer, Medford, MA (US);
Brian L. Hodous, Cambridge, MA (US);
Stuart C. Chaffee, Boston, MA (US);
Paul Tempest, Boston, MA (US);
Ning Xi, Thousand Oaks, CA (US);
Phillip R. Olivieri, Charlestown, MA (US);
Joseph L. Kim, Wayland, MA (US);
Steven Bellon, Wellesley, MA (US);
Xiaotian Zhu, Newton, MA (US);
Yuan Cheng, Newbury Park, CA (US);
Brian K. Albrecht, Cambridge, MA (US);
Vinod F. Patel, Acton, MA (US);
Victor J. Cee, Thousand Oaks, CA (US);
Karina Romero, Cambridge, MA (US);
Hanh Nho Nguyen, Arlington, MA (US);
Holly L. Deak, Brookline, MA (US);
Rebecca E. Johnson, Arlington, VA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, Hand Rare defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.