The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2011
Filed:
Oct. 30, 2006
Joshua Close, Franklin, MA (US);
Richard W. Heidebrecht, Jr., Brookline, MA (US);
Solomon Kattar, Arlington, MA (US);
Thomas A. Miller, Brookline, MA (US);
David Sloman, Boston, MA (US);
Matthew G Stanton, Medfield, MA (US);
Paul Tempest, Brookline, MA (US);
David J. Witter, Norfolk, MA (US);
Joshua Close, Franklin, MA (US);
Richard W. Heidebrecht, Jr., Brookline, MA (US);
Solomon Kattar, Arlington, MA (US);
Thomas A. Miller, Brookline, MA (US);
David Sloman, Boston, MA (US);
Matthew G Stanton, Medfield, MA (US);
Paul Tempest, Brookline, MA (US);
David J. Witter, Norfolk, MA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to a novel class of histone deacetylase inhibitors with aryl-pyrazolyl motifs. The compounds of this invention can be used to treat cancer. The compounds of this invention are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The present invention further provides pharmaceutical compositions comprising the compounds of this invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the compounds of this invention in vivo.