Company Filing History:
Years Active: 2021-2025
Title: Innovations of Nicholas M Marshall
Introduction
Nicholas M Marshall is a prominent inventor based in Rahway, NJ (US), known for his significant contributions to the field of biotechnology. With a total of 10 patents to his name, he has made remarkable advancements in enzyme engineering and pharmaceutical applications.
Latest Patents
One of his latest patents involves engineered phosphopentomutase variant enzymes. This invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides with PPM activity, and polynucleotides encoding these enzymes. It also includes vectors and host cells that comprise these polynucleotides and polypeptides. Methods for producing PPM enzymes are outlined, along with compositions that utilize these engineered enzymes, particularly in the production of pharmaceutical compounds.
Another notable patent focuses on ketoreductase polypeptides and polynucleotides. This invention presents engineered ketoreductase and phosphite dehydrogenase enzymes that exhibit improved properties compared to their naturally occurring counterparts. It includes polynucleotides encoding these engineered enzymes, host cells capable of expressing them, and methods for using these enzymes to synthesize chiral catalysts for antiviral compounds, such as nucleoside inhibitors. Additionally, it provides methods for deracemizing a chiral alcohol in a one-pot, multi-enzyme system.
Career Highlights
Nicholas M Marshall is currently associated with Codexis, Inc., where he continues to innovate and develop new technologies in enzyme engineering. His work has significantly impacted the pharmaceutical industry, particularly in the synthesis of complex compounds.
Collaborations
He collaborates with talented coworkers, including Jovana Nazor and Agustina Rodriguez-Granillo, contributing to a dynamic research environment that fosters innovation and creativity.
Conclusion
Nicholas M Marshall's contributions to enzyme engineering and biotechnology exemplify the spirit of innovation in the field. His patents not only advance scientific knowledge but also hold the potential for significant applications in pharmaceuticals.