Nicholas Hannan is a prominent inventor based in Cambridge, GB. He has made significant contributions to the field of biotechnology, particularly in the expansion and production of cholangiocytes. With a total of four patents to his name, Hannan's work has the potential to impact medical applications significantly.

Latest Patents

Hannan's latest patents include innovative methods for expanding cholangiocytes. One of his inventions focuses on the expansion of primary cholangiocytes in the form of cholangiocyte organoids (COs). This method utilizes culture conditions that inhibit canonical Wnt signaling while potentiating non-canonical Wnt/PCP signaling. Additionally, he has developed methods for the in vitro production of cholangiocyte progenitor (CP) cells. This process involves culturing foregut stem cells (FSCs) in a specialized medium to produce hepatoblasts, which are then matured into cholangiocyte-like cells (CLCs) that exhibit functional properties of Common Bile Duct (CBD) cholangiocytes.

Career Highlights

Nicholas Hannan is associated with Cambridge Enterprise Limited, where he continues to advance his research and innovations. His work is characterized by a strong focus on the medical applications of expanded cholangiocytes, which could lead to breakthroughs in treating liver and biliary diseases.

Collaborations

Hannan collaborates with notable colleagues, including Ludovic Vallier and Fotios Sampaziotis. Their combined expertise enhances the research and development of innovative solutions in the field of biotechnology.

Conclusion

Nicholas Hannan's contributions to the field of biotechnology through his patents and collaborations highlight his role as a leading inventor. His work on cholangiocyte expansion and production has the potential to revolutionize medical treatments and improve patient outcomes.

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