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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12203099 B1

PDFFull Text
Date of Patent:
Jan. 21, 2025

Filed:

Jun. 19, 2018

Methods of expanding cholangiocytes

Applicant:

Cambridge Enterprise Limited, Cambridge, GB;

Inventors:

Ludovic Vallier, Cambridge, GB;

Nicholas Hannan, Cambridge, GB;

Kourosh Saeb-Parsy, Cambridge, GB;

Fotios Sampaziotis, Cambridge, GB;

Assignee:

CAMBRIDGE ENTERPRISE LIMITED, Cambridge, GB;

Attorney:

HAMILTON, BROOK, SMITH & REYNOLDS, P.C.

Primary Examiner:

Arthur S Leonard

Assistant Examiner:

Joseph Paul Miano

Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/413 (2015.01); A61P 1/16 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0679 (2013.01); A61K 35/413 (2013.01); A61P 1/16 (2018.01); C12N 2501/11 (2013.01); C12N 2501/415 (2013.01); C12N 2513/00 (2013.01); G01N 2800/52 (2013.01);
Abstract

This invention relates to the expansion of primary cholangiocytes in the form of cholangiocyte organoids (COs) using culture conditions in which canonical Wnt signalling is inhibited and non-canonical Wnt/PCP signalling is potentiated. Methods of expanding primary cholangiocytes, expanded populations of cholangiocytes and medical applications of expanded cholangiocytes are provided.

Find Patent Forward Citations

Vallier, Ludovic. (2025). Methods of expanding cholangiocytes (U.S. Patent No. 12203099). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12203099

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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