Company Filing History:

7 out of 24

Orchid Biosciences, Inc.

patents

5 out of 2,307

University of Minnesota

patents

2 out of 590

Beckman Coulter, Inc.

patents

4. 1 out of 4

Orchid Biocomputer, Inc.

patents

Years Active: 1995-2005

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15 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 6946249 - De novo or 'universal' sequencing array (2005-09-20),

2. 6872521 - Polymerase signaling assay (2005-03-29),

3. 6387626 - Covalent attachment of unmodified nucleic acids to silanized solid phase surfaces (2002-05-14),

4. 6337188 - De novo or “universal” sequencing array (2002-01-08),

5. 6322968 - De novo or “universal” sequencing array (2001-11-27),

6. 6294336 - Method for analyzing the nucleotide sequence of a polynucleotide by oligonucleotide extension on an array (2001-09-25),

7. 6287821 - Nucleotide analogues with 3'-pro-fluorescent fluorophores in nucleic acid sequence analysis (2001-09-11),

8. 6235473 - Gene pen devices for array printing (2001-05-22),

9. 6136962 - Covalent attachment of unmodified nucleic acids to silanized solid phase (2000-10-24),

10. 5972604 - DNA sequence-based HLA typing method (1999-10-26),

11. 5919626 - Attachment of unmodified nucleic acids to silanized solid phase surfaces (1999-07-06),

12. 5629149 - DNA sequence-based HLA typing method (1997-05-13),

13. 5593830 - DNA sequence-based HLA class I typing method (1997-01-14),

14. 5578443 - DNA sequence-based HLA typing method (1996-11-26),

15. 5424184 - DNA sequence-based HLA class I typing method (1995-06-13),

Title: Michael T Boyce-Jacino: Innovator in Nucleic Acid Sequencing

Introduction

Michael T Boyce-Jacino is a prominent inventor based in Finksburg, MD (US), known for his significant contributions to the field of nucleic acid sequencing. With a total of 15 patents to his name, he has made remarkable advancements that have the potential to transform genetic analysis and diagnostics.

Latest Patents

Among his latest patents is the "De novo or 'universal' sequencing array." This invention describes a novel nucleic acid sequencing reagent that consists of a capture moiety, a spacer region, and a sequence-specific hybridizing region of 4-8 bases. The reagent can also include an attachment moiety and can be arranged into a nested array. This configuration allows for sequencing a given template without prior knowledge of the wild type or expected sequence, in conjunction with primer extension using a labeled chain-terminating nucleotide. Another notable patent is the "Polymerase signaling assay," which relates to nucleic acid sequence analysis. This invention provides methods for performing a polymerase signal assay (PSA) to analyze nucleotide sequences using solid-phase sequence arrays comprising a plurality of sequence reagents with primer sequences 4-6 bases in length. The methods generate a binary signal pattern that can identify nucleic acid sequences, mutations, and polymorphisms, including single nucleotide polymorphisms (SNPs), base deletions, and insertions.

Career Highlights

Michael has worked with several notable organizations, including Orchid Biosciences, Inc. and the University of Minnesota. His work in these institutions has allowed him to further develop his innovative ideas and contribute to the scientific community.

Collaborations

Throughout his career, Michael has collaborated with esteemed colleagues such as Pedro Santamaria and Jose J Barbosa. These partnerships have fostered a collaborative environment that has enhanced the development of his inventions.

Conclusion

Michael T Boyce-Jacino is a distinguished inventor whose work in nucleic acid sequencing has paved the way for advancements in genetic analysis. His innovative patents and collaborations reflect his commitment to pushing the boundaries of science and technology.

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