Location History:
- Lorrach, DE (2013)
- München, DE (2010 - 2014)
- Munich, DE (2016)
- Loerrach, DE (2014 - 2024)
Company Filing History:
8 out of 3,923 
3 out of 88 
2 out of 168 
Years Active: 2010-2024
Title: **The Innovations of Michael Otto Bardroff: A Pioneer in Bispecific Antibody Development**
Introduction
Michael Otto Bardroff, an accomplished inventor based in Loerrach, Germany, has made significant contributions to the field of biotechnology through his innovative work on bispecific antibodies. With a remarkable portfolio of 11 patents, Bardroff's inventions continue to pave the way for new therapeutic applications that address various autoimmune and inflammatory diseases.
Latest Patents
Among his latest innovations, Bardroff has developed a method of manufacturing bispecific antibodies and their therapeutic uses. This invention focuses on bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof. The method involves co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies within mammalian cell lines, significantly enhancing the efficiency of antibody production.
Another groundbreaking patent concerns Interleukin-18 (IL-18) binding molecules. IL-18 plays a crucial role in both innate and acquired immunity and is regulated by naturally occurring inhibitors like IL-18 binding protein (IL18BP). Bardroff's invention details binding molecules, specifically antibodies or their fragments, designed to bind IL-18 while not interacting with the IL-18/IL-18BP complex. This advancement has vast potential applications, not only as therapeutic agents for IL-18-related diseases but also as diagnostic tools for evaluating IL-18 levels in various medical contexts.
Career Highlights
Michael Otto Bardroff has displayed an impressive career in the biotechnology sector, notably working with prestigious companies such as Novartis AG and MorphoSys AG. His expertise in monoclonal antibody production and therapeutic applications has enhanced the development of next-generation biopharmaceuticals.
Collaborations
Throughout his career, Bardroff has collaborated with several notable experts in the field, including Bernd Bohrmann and Manfred Brockhaus. These partnerships have further enriched his contributions to antibody research and development, leading to innovative solutions in treating complex diseases.
Conclusion
Michael Otto Bardroff stands out as a visionary inventor whose work significantly impacts the biotechnology landscape. His patents, particularly in the realm of bispecific antibodies and IL-18 binding molecules, highlight the important intersection of science and therapeutic innovation. As the healthcare industry continues to evolve, Bardroff's contributions will undoubtedly play a vital role in shaping future treatments for autoimmune and inflammatory diseases.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.