The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Aug. 24, 2018
Novartis Ag, Basel, CH;
Michael Otto Bardroff, Loerrach, DE;
Barbara Brannetti, Boston, MA (US);
Emma Michelle Campbell, Surbiton, GB;
Beate Diefenbach-Streiber, Windach, DE;
Adina Eberth, Munich, DE;
Christian Carsten Silverster Kunz, Munich, DE;
Sylwia Marshall, Huntingdon, GB;
Jean-Michel Rene Rondeau, Rixheim, FR;
Jean-Marc Alfred Schlaeppi, Allschwil, CH;
Gino Anselmus Van Heeke, Upper Beeding, GB;
NOVARTIS AG, Basel, CH;
Abstract
Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.