Location History:
- Cambridge, MA (US) (2022 - 2023)
- Boston, MA (US) (2021 - 2024)
Company Filing History:
30 out of 443 
2 out of 8 Years Active: 2021-2025
Title: The Innovative Contributions of Mark K Schlegel
Introduction
Mark K Schlegel, based in Boston, MA, is a prolific inventor with an impressive portfolio comprising 21 patents. His work primarily focuses on advancements in biotechnology and therapeutic applications, reflecting a strong commitment to addressing complex healthcare challenges.
Latest Patents
Among his latest innovations, Schlegel has developed modified RNA agents designed to achieve reduced off-target effects. This invention involves double-stranded RNA (dsRNA) capable of inhibiting the expression of target genes. Notably, the antisense strand of the dsRNA molecule contains thermally destabilizing nucleotides at the seed region, along with four 2'-fluoro modifications. The sense strand incorporates a ligand for ASGPR, opening new avenues for pharmaceutical compositions aimed at treating various disease conditions. Additionally, Schlegel has also worked on hepatitis B virus (HBV) dsRNA agents, which target the HBV genome and provide methods to inhibit the expression of HBV genes, presenting new treatment possibilities for chronic hepatitis B infections.
Career Highlights
Schlegel has held positions at prominent biotech companies such as Alnylam Pharmaceuticals, Inc. and Vir Biotechnology, Inc. His extensive experience in these organizations further emphasizes his role as a leader in the development of RNA-based therapeutics.
Collaborations
Throughout his career, Mark K Schlegel has collaborated with distinguished colleagues, including James D McIninch and Adam Castoreno. These partnerships have likely fostered an environment of innovation, allowing for the exchange of ideas and knowledge that propel advancements in biotechnology.
Conclusion
Mark K Schlegel's contributions to the field of biotechnology and his multitude of patents illustrate his significant impact on medical science. His innovative work in RNA technologies plays a crucial role in developing new treatments for viral infections and beyond, marking him as a key figure in the ongoing evolution of therapeutic strategies.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.