The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2025
Filed:
Apr. 27, 2021
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
Applicant:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Frederic Tremblay, Boston, MA (US);
James D. Mcininch, Burlington, MA (US);
Adam Castoreno, Framingham, MA (US);
Mark K. Schlegel, Boston, MA (US);
Charalambos Kaittanis, Cambridge, MA (US);
Assignee:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 9/08 (2006.01); A61K 47/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 9/08 (2013.01); A61K 47/02 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3125 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/346 (2013.01); C12N 2310/351 (2013.01);
Abstract
The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and to methods of preventing and treating an PNPLA3-associated disorder, e.g., Nonalcoholic Fatty Liver Disease (NAFLD).