Location History:
- Slough Berkshire, GB (2020)
- Slough, GB (2017 - 2024)
Company Filing History:
5 out of 138 
4 out of 109 
2 out of 1,451 
Years Active: 2017-2024
Title: The Innovative Contributions of Mark Daniel Calmiano
Introduction
Mark Daniel Calmiano is a notable inventor based in Slough, GB. He has made significant contributions to the field of pharmaceuticals, particularly in the development of compounds that modulate human TNFα activity. With a total of nine patents to his name, Calmiano's work has the potential to impact various medical conditions.
Latest Patents
Among his latest patents, Calmiano has developed a series of fused pentacyclic imidazole derivatives. These compounds are recognized for their potential benefits in treating and preventing a range of human ailments, including autoimmune and inflammatory disorders, neurological and neurodegenerative disorders, pain and nociceptive disorders, cardiovascular disorders, metabolic disorders, ocular disorders, and oncological disorders. One specific invention focuses on 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and their analogs. Another significant patent involves a method for identifying potential inhibitors of APO TNFα trimers. This invention discloses a new, stable trimeric TNFα structure that can bind to the TNFR1 receptor, thereby attenuating signaling and offering therapeutic options for diseases associated with the soluble TNFα/TNFR1 interaction.
Career Highlights
Calmiano has worked with prominent companies in the pharmaceutical industry, including UCB Biopharma Sprl and UCB Biopharma Srl. His experience in these organizations has contributed to his expertise in drug development and innovation.
Collaborations
Throughout his career, Calmiano has collaborated with notable colleagues such as Boris Kroeplien and Matthew Duncan Selby. These partnerships have likely enhanced his research and development efforts.
Conclusion
Mark Daniel Calmiano's innovative work in the pharmaceutical field demonstrates his commitment to advancing medical science. His patents reflect a deep understanding of complex biological interactions and a dedication to improving human health.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.