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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9550737 B1

PDFFull Text
Date of Patent:
Jan. 24, 2017

Filed:

Jun. 11, 2013

Tnf -α modulating benzimidazoles

Applicant:

Ucb Biopharma Sprl, Brussels, BE;

Inventors:

Daniel Christopher Brookings, Slough, GB;

Mark Daniel Calmiano, Slough, GB;

Ellen Olivia Gallimore, Slough, GB;

Helen Tracey Horsley, Slough, GB;

Martin Clive Hutchings, Slough, GB;

James Andrew Johnson, Slough, GB;

Boris Kroeplien, Slough, GB;

Fabien Claude Lecomte, Slough, GB;

Martin Alexander Lowe, Slough, GB;

Timothy John Norman, Slough, GB;

John Robert Porter, Slough, GB;

Joanna Rachel Quincey, Slough, GB;

James Thomas Reuberson, Slough, GB;

Matthew Duncan Selby, Slough, GB;

Michael Alan Shaw, Slough, GB;

Zhaoning Zhu, Slough, GB;

Anne Marie Foley, Slough, GB;

Assignee:

UCB Biopharma SPRL, Brussels, BE;

Attorney:

McDonnell Boehnen Hulbert & Berghoff LLP

Primary Examiner:

Sahar Javanmard

Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 491/107 (2006.01); C07D 235/12 (2006.01); A61K 31/4184 (2006.01); A61K 31/4192 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/454 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/551 (2006.01); C07D 405/06 (2006.01);
U.S. Cl.
CPC ...
C07D 235/12 (2013.01); A61K 31/4184 (2013.01); A61K 31/4192 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/551 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/06 (2013.01); C07D 491/107 (2013.01);
Abstract

A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

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