The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2018
Filed:
Dec. 08, 2014
Ucb Biopharma Sprl, Brussels, BE;
Rikki Peter Alexander, Slough, GB;
Mark Daniel Calmiano, Slough, GB;
Sabine Defays, Brussels, BE;
Veronique Durieu, Brussels, BE;
Michael Deligny, Brussels, BE;
Jag Paul Heer, Brussels, BE;
Victoria Elizabeth Jackson, Slough, GB;
Jean Keyaerts, Brussels, BE;
Boris Kroeplien, Slough, GB;
Malcolm Mac Coss, Seabrook Island, SC (US);
Yogesh Anil Sabnis, Brussels, BE;
Matthew Duncan Selby, Slough, GB;
Dominique Louis Leon Swinnen, Brussels, BE;
Nathalie Van Houtvin, Brussels, BE;
Zhaoning Zhu, Slough, GB;
Uwe Heinelt, Frankfurt am Main, DE;
Volkmar Wehner, Frankfurt am Main, DE;
UCB BIOPHARMA SPRL, Brussels, BE;
Abstract
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole, dihydro-1H-pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.