The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 26, 2018

Filed:

Dec. 08, 2014
Applicant:

Ucb Biopharma Sprl, Brussels, BE;

Inventors:

Julien Alistair Brown, Slough, GB;

Mark Daniel Calmiano, Slough, GB;

Elizabeth Pearl Jones, Slough, GB;

Boris Kroeplien, Slough, GB;

James Thomas Reuberson, Slough, GB;

Matthew Duncan Selby, Slough, GB;

Michael Alan Shaw, Slough, GB;

Zhaoning Zhu, Slough, GB;

Assignee:

UCB BIOPHARMA SPRL, Brussels, BY;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/437 (2006.01); A61K 31/444 (2006.01); A61K 31/5377 (2006.01); A61K 31/4985 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/5377 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01); A61K 31/4985 (2013.01); A61K 45/06 (2013.01);
Abstract

A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5-α]pyridine derivatives, and analogs thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.


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